Key features and details | |
Cat. No. | MABL-2797 |
Name | Anti-RANK-L mAbs |
Clone No. | AFD- 14F3 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | inhibition, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for human-RANK-L. It does not recognize murine RANK-L. RANKL is a tumor necrosis factor (TNF)-related protein that binds to, and activates, the TNF receptor (TNFR)-related protein Receptor Activator of NF-kB (RANK). RANKL acts as the key cytokine that regulates osteoclast differentiation and activation during normal bone remodeling and during disease |
Alternative Name | CD254; TRANCE; RANKL; ODF; OPGL; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear factor kappa-B ligand; TNF-related activation-induced cytokine |
UniProt | O14788 |
Immunogen | The original antibody was generated by immunizing CB6 fl mice with human RANKL protein. |
Application Notes | The specificity of the original version of the antibody was confirmed by ELISA analysis (IC50 = 2 nM). The antibody specifically inhibits the functional activity of RANKL induction of DC maturation. The antibody could strongly inhibit the interaction between human RANKL and its receptor RANK in human monocytes. The inhibition led to antagonism of RANKL-mediated DC maturation and osteoclast development and function (US20040213788). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
