Anti-RANK-L mAbs

Cat. No.

MABL-2798

Name

Anti-RANK-L mAbs

Clone No.

AFD- 2A4

From

Recombinant Antibody

Isotype

Engineer antibody

Application

ELISA

Species Reactivity

Human

Basic Information

Specificity

The antibody is specific for human-RANK-L. RANKL   is a tumor necrosis factor related protein that binds to, and activates, the   TNF receptor related protein Receptor Activator of NF-kB (RANK). RANKL acts   as the key cytokine that regulates osteoclast differentiation and activation   during normal bone remodeling and during disease

Alternative Name

CD254; TRANCE; RANKL; PAE30; ODF; OPGL;   Tumor necrosis factor ligand superfamily member 11; Osteoclast   differentiation factor; Osteoprotegerin ligand; Receptor activator of nuclear   factor kappa-B ligand; TNF-related activation-induced cytokine

UniProt

O14788

Immunogen

The original antibody was generated by   immunizing CB6 f1 mice with human RANKL protein.

Application Notes

The specificity of the original format of the   antibody was confirmed by ELISA analysis (IC50 = 2 nM). The original format   of the antibody blocked the maturation of cells treated with sRANKL, the   antibody specifically inhibits the functional activity of RANKL induction of   dendritic cells maturation. The original format of the antibody promoted the   inhibition of human sRANKL-stimulated bone marrow murine osteoclastogenesis   in cell culture. These results showed that the original format of the   antibody is a potent inhibitor of the interaction between human RANKL and its   receptor RANK (US20030215450A1).

Antibody First   Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.