Key features and details | |
Cat. No. | MABL-2754 |
Name | Anti-Progesterone mAbs |
Clone No. | AFD- 11/32 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | RIA, Block |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody recognizes and binds progesterone. It also cross reacts with other steroids like 5,α-pregnanedione. |
Alternative Name | P4; pregn-4-ene-3,20-dione |
UniProt | |
Immunogen | The original antibody was generated by immunizing BALB/c mice with 11-α- hydroxyprogesterone-11-hemisuccinyl-bovine serum albumin (BSA) conjugate. |
Application Notes | This antibody binds progesterone, which is an endogenous steroid female sex hormone, involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. The hormone is produced by the corpus luteum in the ovaries and later by the placenta during pregnancy and is necessary for maintenance of pregnancy as it prevents the breakdown of the endometrium. This antibody against progesterone may be used for the study its role in the female reproductive system and uring pregnancy. It may also be used as an immunological prevention of pregnancy. The antibody is reported to have blocking effects and prevention of pregnancy in mice (PMID：7057905). Passive immunization of mice with this antibody has anti-fertility effects by blocking implantation (PMID：2373979, 3411286). This antibody is also reported to cross react with other steroids (PMID: 3123368, 7632616). |
Antibody First Published | Wright et al. Progesterone monoclonal antibody blocks pregnancy in mice. Nature (1982), Issue: 5848, Volume: 295, Page: 415-417. PMID:7057905 |
Note on publication | Describes the generation and charactierization of the antibody and its role in blocking the establishment of pregnancy in mice. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
