Anti-CART mAbs

Cat. No.

MABL-254

Name

Anti-CART mAbs

Clone No.

AFD-AH36

From

Recombinant Antibody

Isotype

Engineer antibody

Application

in vivo, ELISA

Species Reactivity

Species independent

Basic Information

Specificity

This antibody specifically binds   cocaine-amphetamine regulated transcript peptide also known as CART, which is   a widely distributed neurotransmitter expressed in the central nervous   systems. Studies have shown the role of CART in food intake, maintenance of   bodyweight, stress control, reward and pain transmission. Repeated   administration of psychostimulants enhances expression of CART peptide. Nucleus accumbal-injected CART peptide plays a positive role in the   regulation of behavioral sensitization induced by psychostimulants and  regulated the mesocorticolimbic dopaminergic pathway. CART peptide also   exerted an inhibitory effect on psychostimulant-enhanced dopamine receptors   signaling, Ca2+/calmodulin- dependent kinase signaling and crucial   transcription factors expression.

Alternative Name

CARTPT; Cocaine-amphetamine regulated   transcript peptide; neurotransmitter

UniProt

Immunogen

Application Notes

The binding reactivity of this antibody to  CART was checked using ELISA. The in-vivo administration of this antibody in mice had no effects on the normal spontaneous activities of the animal.   However, when mice were given this antibody intraperitoneally before   administration of cocaine, it inhibited the expression of cocaine-induced   animal behavioral sensitization (CN101280016). This antibody is recommended   for studies relating to treatment of drug addiction.

Antibody First Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.