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Anti-Snake venom metalloproteinase BaP1 mAbs

简要描述:

This antibody reacts with snake venom metalloproteinase (SVMP) BaP1 present in the venom of Bothrops asper. BaP1 is a P-I class of SVMP relevant in the local tissue damage associated with envenomations by Bothrops asper. This metalloproteinase exhibits a weak hemorrhagic activity and rapidly degrades the Aalpha-chain (FGA) of fibrinogen, and later on, degrades the Bbeta-chain (FGB) of fibrinogen.

产品参数:

Cat. No.:MABL-2942

Species:Engineer

Species Reactivity:Bothrops asper (Terciopelo), Bothrops neuwiedi

Type:Recombinate

Application:neutralize, ELISA

详细介绍

Key features and   details


Cat. No.

MABL-2942

Name

Anti-Snake venom metalloproteinase BaP1 mAbs

Clone No.

AFD- MABaP1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

neutralize, ELISA

Species Reactivity

Bothrops asper (Terciopelo), Bothrops   neuwiedi

Basic Information


Specificity

This antibody reacts with snake venom   metalloproteinase (SVMP) BaP1 present in the venom of Bothrops asper. BaP1 is a P-I class of SVMP relevant in the local tissue damage associated with   envenomations by Bothrops asper. This metalloproteinase exhibits a weak   hemorrhagic activity and rapidly degrades the Aalpha-chain (FGA) of   fibrinogen, and later on, degrades the Bbeta-chain (FGB) of fibrinogen.

Alternative Name

BaP1; Hemorrhagic metalloproteinase BaP1;   BnP1

UniProt

P83512

Immunogen

The original antibody was generated by   immunizng BALB/c mice with 10 mg BaP1 obtained from B. asper venom emulsified   in incomplete Marcol/Montanide adjuvant.

Application Notes

The antibody can bind snake venom   metalloproteinases BaP1, whole venom of B. asper and BnP1 (B. neuwiedi) in an   ELISA. This antibody completely neutralized in vivo hemorrhage, muscle  necrosis, and inflammation induced by the toxin. This antibody completely   neutralize myotoxicity induced by BaP1. In general it was capable of   neutralizing biological effects of this SVMP (PMID: 20674587; 20674587).

Antibody First   Published

Fernandes et al. Immunochemical and   biological characterization of monoclonal antibodies against BaP1, a   metalloproteinase from Bothrops asper snake venom. Toxicon. 2010   Nov;56(6):1059-65. doi: 10.1016/j.toxicon.2010.07.014. PMID:20674587

Note on publication

 Describes the generation of a neutralizing   antibody against snake venom metalloproteinase BaP1 of Bothrops asper.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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