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Anti-Snake venom metalloproteinase TM-3 mAbs

简要描述:

This antibody reacts specifically with snake venom metalloproteinase (SVMP) TM-3 present in the venom of Protobothrops mucrosquamatus. SVMP is a potent fibrinogenolytic protease which cleaves mainly the alpha chain of fibrinogen (FGA) and slightly the beta (FGB) and the gamma (FGG) chains. It has hemorrhagic activity.

产品参数:

Cat. No.:MABL-2943

Species:Engineer

Species Reactivity:Protobothrops mucrosquamatus (Taiwan habu, Trimeresurus mucrosquamatus)

Type:Recombinate

Application:WB, ELISA

详细介绍

Key features and   details


Cat. No.

MABL-2943

Name

Anti-Snake venom metalloproteinase TM-3 mAbs

Clone No.

AFD- SVMP-mc18

From

Recombinant Antibody

Isotype

Engineer antibody

Application

WB, ELISA

Species Reactivity

Protobothrops mucrosquamatus (Taiwan habu,   Trimeresurus mucrosquamatus)

Basic Information


Specificity

This antibody reacts specifically with snake   venom metalloproteinase (SVMP) TM-3 present in the venom of Protobothrops   mucrosquamatus. SVMP is a potent fibrinogenolytic protease which cleaves   mainly the alpha chain of fibrinogen (FGA) and slightly the beta (FGB) and   the gamma (FGG) chains. It has hemorrhagic activity.

Alternative Name

SVMP; SVMP protein; SVMP TM-3; Atrolysin e;   Fibrinlysin; Trimutase; Zinc metalloproteinase/disintegrin

UniProt

O57413

Immunogen

The original antibody was generated by   immunizing BALB/c mice with natural snake venom metalloproteinase TM-3   purified from crude venom of Protobothrops mucrosquamatus.

Application Notes

This antibody can be used for the detection   of SVMP protein of Trimeresurus mucrosquamatus by ELISA. The binding   specifcity of the antibody was further confirmed by detection of the protein   in a western blot (CN113832132; PMID: 34899734).

Antibody First   Published

Long et al. A Strategy for Efficient   Preparation of Genus-Specific Diagnostic Antibodies for Snakebites. Front   Immunol. 2021 Nov 9:12:775678. PMID:34899734

Note on publication

Describes the generation of monoclonal and polyclonal antibodies against SVMP protein and PLA2 protein found in snake venom.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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