Key features and details | |
Cat. No. | MABL-2943 |
Name | Anti-Snake venom metalloproteinase TM-3 mAbs |
Clone No. | AFD- SVMP-mc18 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, ELISA |
Species Reactivity | Protobothrops mucrosquamatus (Taiwan habu, Trimeresurus mucrosquamatus) |
Basic Information | |
Specificity | This antibody reacts specifically with snake venom metalloproteinase (SVMP) TM-3 present in the venom of Protobothrops mucrosquamatus. SVMP is a potent fibrinogenolytic protease which cleaves mainly the alpha chain of fibrinogen (FGA) and slightly the beta (FGB) and the gamma (FGG) chains. It has hemorrhagic activity. |
Alternative Name | SVMP; SVMP protein; SVMP TM-3; Atrolysin e; Fibrinlysin; Trimutase; Zinc metalloproteinase/disintegrin |
UniProt | O57413 |
Immunogen | The original antibody was generated by immunizing BALB/c mice with natural snake venom metalloproteinase TM-3 purified from crude venom of Protobothrops mucrosquamatus. |
Application Notes | This antibody can be used for the detection of SVMP protein of Trimeresurus mucrosquamatus by ELISA. The binding specifcity of the antibody was further confirmed by detection of the protein in a western blot (CN113832132; PMID: 34899734). |
Antibody First Published | Long et al. A Strategy for Efficient Preparation of Genus-Specific Diagnostic Antibodies for Snakebites. Front Immunol. 2021 Nov 9:12:775678. PMID:34899734 |
Note on publication | Describes the generation of monoclonal and polyclonal antibodies against SVMP protein and PLA2 protein found in snake venom. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
