Key features and details | |
Cat. No. | MABL-371 |
Name | Anti-alpha V beta 8 integrin mAbs |
Clone No. | AFD- EM13309 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, ELISA, FC, IHC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for the extracellular domain of human recombinant transmembranetruncated (DTM) αvβ8 integrin, a dimeric cell surface protein that mediates cell attachment. αvβ8 integrin promotes the activation of latent TGF-β, as well as inhibiting tumor cell growth. |
Alternative Name | αvβ8; Vitronectin receptor subunit alpha; CD51; Integrin beta-8; ITGB8; P06756; P26012; avb8 |
UniProt | |
Immunogen | This antibody was raised by immunizing rabbits, isolating B cells from the immunized rabbits, and fusing these with a rabbit plasmacytoma cell line (established by Spieker-Polet et al., 1995) to produce stable hybridomas. |
Application Notes | This antibody has been used to specifically bind αvβ8 in Western blots and flow cytometry and to specifically stain αvβ8 integrins in FFPE (formalin-fixed paraffin-embedded) or TMA material, where murine antibodies function poorly (Goodman et al., 2012; PMID |
Antibody First Published | |
Note on publication | Goodman et al. Matched rabbit monoclonal antibodies against αv-series ntegrins reveal a novel αvβ3-LIBS epitope, and permit routine staining of archival paraffin samples of human tumours Biol Open. 2012 Apr 15; 1 |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
