Key features and details | |
Cat. No. | MABL-2356 |
Name | Anti-Methylene diphenyl diisocyanate mAbs |
Clone No. | AFD- AH6 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, ELISA |
Species Reactivity | Species independent |
Basic Information | |
Specificity | |
Alternative Name | MDI |
UniProt | |
Immunogen | Mouse serum protein conjugated with MDI. |
Application Notes | The antibody binds specifically to MDI, a low-molecular weight aromatic diisocyanate which is commonly used to make polyurethane. MDI is also a major cause of occupational asthma, due to its ability to sensitize the immune system and elicit an immune response. In humans, the carrier protein albumin is able to recognise and conjugate with MID, forming a complex which is bound by IgE, triggering an asthmatic attack. Monoclonal antibodies directed against MID can be applied to diagnostics and research,and can be used to detect and quantitate MID levels in blood and urine, as well as in environmental samples. Monoclonal antibodies AD3 and AH6 bind to similar or overlapping epitopes. |
Antibody First Published | Wisnewski AV, Liu J. Molecular determinants of humoral immune specificity for the occupational allergen, methylene diphenyl diisocyanate. Mol Immunol. 2013 Jun;54(2):233-7. PMID:23295252 |
Note on publication | Describes the production of six monoclonal antibodies directed against MDI, which could be developed into useful diagnostic reagents. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
