Anti-Ferritin mAbs

Cat. No.

MABL-1573

Name

Anti-Ferritin mAbs

Clone No.

AFD- AMB8LK

From

Recombinant Antibody

Isotype

Engineer antibody

Application

immunotherapy, IP, tumor imaging

Species Reactivity

Human

Basic Information

Specificity

This antibody binds human ferritin. This   protein catalyzes the oxidation of ferrous iron(II) to ferric iron(III) and   stores iron in a soluble, non-toxic, readily available form. Ferritin is   important for iron homeostasis.

Alternative Name

FTMT; FTL; FTH1; Ferritin mitochondrial; B8

UniProt

Q8N4E7

Immunogen

The original antibody was generated by   immunizing female Balb/c mice with ferritin extracted from human spleen   cells.

Application Notes

This antibody was capable of  immunoprecipitating ferritin (PMID: 6817879). The original antibody binds   human ferritin with a binding affinity of Kd= 5.1nM (EP2193147). The   thiolated version of this antibody was conjugated to maleimide-activated   polylactide nanoparticles (NPs) to generate immunonanoparticles, which may   carry drugs to desired overexpressing antigen cells potentially leading to   improved drug therapy and reduced systemic adverse effects (PMID: 19835957).  Preclinical studies showed that the immunoconjugate with 90Y has 98%   stability over 7 days. A very good pancreatic adenocarcinoma tumor targeting   was observed especially with the Bz-DTPA-AMB8LK (PMID: 17383579)

Antibody First   Published

Kadouche et al. Analysis of various   isoferritins with monoclonal antibodies. C R Seances Acad Sci III. 1982 Oct   18;295(6):443-8. PMID:6817879

Note on publication

Describes the generation and   characterization of 4 antibodies against isoferritins.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.