Key features and details | |
Cat. No. | MABL-1569 |
Name | Anti-FcRn mAbs |
Clone No. | AFD- h22-0015 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, in vitro, in vivo |
Species Reactivity | Human |
Basic Information | |
Specificity | The antibody is specific for human FcRn. The neonatal Fc receptor is a cell surface receptor that transfers passive humoral immunity from the mother to the newborn. |
Alternative Name | IgG receptor FcRn large subunit p51; FCGRT; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor |
UniProt | P55899 |
Immunogen | The original antibody was generated by immunizing Balb/c mice with recombinant FcRn. |
Application Notes | The antibody was employed in blocking experiments with HEK293 cells that overexpress FcRn. The results showed that the antibody has a good effect of blocking the binding of IgG to FcRn at the cellular level (IC50: 11.4nM). The effect of the antibody was tested in human FcRn transgenic mice. The antibody was able to increase IgG catabolism in vivo by blocking FcRn binding (CN113484526). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
