Anti-Factor VIII:c light chain mAbs

Cat. No.

MABL-1557

Name

Anti-Factor VIII:c light  chain mAbs

Clone No.

AFD- RFF-VIII:c/5

From

Recombinant Antibody

Isotype

Engineer antibody

Application

column chromatography, immunoradiometric assay, Block

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for a C-terminal   site on human coagulation factor VIII

Alternative Name

AHF; Antihemophilic factor; coagulation factor VIII; procoagulant component; coagulation factor VIIIc; DXS1253E; F8Ccoagulation factor VIII; factor VIII F8B; FVIII; HEMAF8B; Procoagulant component

UniProt

P00451

Immunogen

This antibody was raised by immunising   BALB/C mice with highly purified procoagulant factor VIII (VIII: C)

Application Notes

This antibody is a coagulation inhibitor,   though displays only weak anticoagulant activity (Rotblat et al, 1983). It   has been used as the solid-phase immunoadsorbent in a two-site   immunoradiometric assay of Factor VIII:c (Rotblat et al, 1983).When bound to   Sepharose columns, this antibody has been used to deplete factor VII:c from   plasma through column chromatography (Takase et al, 1987).

Antibody First   Published

Rotblat et al. Monoclonal antibodies to   human procoagulant factor VIII. Journal of Laboratory and Clinical Medicine,   June 1983 PMID:6403638

Note on publication

Describes the original generation and   characterisation of this antibody.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.