Anti-Factor VII mAbs

Cat. No.

MABL-1548

Name

Anti-Factor VII mAbs

Clone No.

AFD- RFF-VII/1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

radioimmunoassay, Block

Species Reactivity

Human

Basic Information

Specificity

This antibody is specific for human coagulation factor VII, a serine protease that initiates the extrinsic pathway of coagulation and circulates as a zymogen.

Alternative Name

Coagulation factor VII; factor-VII; EC:3.4.21.21; Proconvertin; Serum prothrombin conversion accelerator; SPCA;   Eptacog alfa

UniProt

P08709

Immunogen

This antibody was raised by immunising   Balb/c mice with purified human factor VII.

Application Notes

This antibody binds with high affinity to human factor VII, and acts as an inhibitor of factor VII coagulation activity   (Takase et al, 1988).When coupled to sepharose, this antibody has been used   to deplete factor VII from plasma (Sarial et al, 2012). The specificity of this antibody for factor VII has been confirmed in a double monoclonal   immunoradiometric assay for factor VII antigen (Takase et al, 1988).

Antibody First   Published

Takase et al. Monoclonal antibodies to human   factor VII: a one step immunoradiometric assay for VII:Ag. J Clin Pathol.   1988 Mar;41(3):337-41. PMID:3360957

Note on publication

Describes the original generation and   characterisation of this antibody.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.