Cat. No.
MABL-3907
Application
ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
Nb16-17
From
Recombinant Antibody
Specificity
This antibody specifically binds an epitope between amino acids 112-195 of human CD9. This protein is an integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Extracellular vesicles (EVs) such as exosomes are important mediators in intercellular communications and play a role in cancer progression and metastasis. Exosomal membranes are enriched in endosome-specific tetraspanins like CD9. EVs have strong potential as blood-based or urine-based biomarkers for the diagnosis, prognostication, and surveillance of cancer.
Alternative Names
p24; MIC3; MRP-1; GIG2; Tspan-29; TSPAN29; 5H9 antigen; Cell growth- inhibiting gene 2 protein; Leukocyte antigen MIC3; Motility-related protein; Tetraspanin-29
UniProt
P21926
Immunogen
The original antibody was generated by immunizing mice with CEA positive adenocarcinoma cells preferably from lungs.
Application Notes
Technetium 99-labeled (Tc-99m) BW431/26 has been used in the diagnosis and detection of colorectal carcinomas, breast cancers, bladder carcinomas, lung adenocarcinomas and their recurrences by immunoscintigraphy (PMID: 2602902, 2662074, 2685692, 2297747, 2157833, 2166552, 2383485, 1984945 ). The use of Tc-99m-BW 431/26 immunoconjugates in immunoscintigraphy resulted in reduction of radiation dose for the patient down to 5% of the dose applied as compared with I-131 labelled MAbs (PMID: 3262953). Humanized version of this antibody also shows similar binding affinity as compared to its murine parent antibody (PMID: 1762576).
Antibody First Published
US6294172
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
