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Anti-CD96 [6A6](MABL-3453)

简要描述:

This antibody is specific for murine CD96, and recognises an epitope in the first Ig domain.

产品参数:

Cat. No.:MABL-3453

Species:Engineer

Species Reactivity:Mouse

Type:Recombinate

Application:Blocking, FC

详细介绍

Key features and   details


Cat. No.

MABL-3453

Name

Anti-CD96 [6A6](MABL-3453)

Clone No.

6A6

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, FC

Species Reactivity

Mouse

Basic Information


Specificity

This antibody is specific for murine CD96, and recognises an epitope in the first Ig domain.

Alternative Name

TACTILE; T-cell surface protein tactile; T cell-activated increased late expression protein

UniProt

Q3U0X8

Immunogen

This antibody was raised by immunising rats with murine CD96.

Application Notes

This antibody blocks murine CD96-CD155 interaction,   and has been shown to bind to the first Ig domain of CD96 and compete with   CD155 binding (Roman Aguilera et al, 2018). This antibody displays   significant anti-metastatic activity in four experimental lung metastases   models and one spontaneous tumour metastasis model (Roman Aguilera et al,   2018), with a potency greater than the anti- CD96 monoclonal antibodies 3.3   and 8B10. The binding specificity of this antibody has been determined in flow cytometric analysis of HEK-293 cells transfected with a range of CD96 Ig   domain chimeric constructs (Roman Aguilera et al, 2018).

Antibody First   Published

Seth et al. The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1. Biochem Biophys Res Commun. 2007 Dec 28;364(4):959-65. PMID:17971293

Note on publication

Describes the original generation of this antibody, and its characterisation.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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