Anti-MERS-CoV Spike Protein mabs [3A1](MABL-3590)

Cat. No.

MABL-3590

Name

Anti-MERS-CoV Spike Protein mabs [3A1](MABL-3590)

Clone No.

3A1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

NTRL

Species Reactivity

MERSCoronavirus

Basic Information

Specificity

This antibody specifcally binds the amino acids 349-590 in the S1 domain of the MERS-CoV.

Alternative Name

Spike gylcoprotein; S glycoprotein; E2; Peplomer protein;Spike protein S1

UniProt

W6A029

Immunogen

The original antibody was generated by isolating neutralizing antibodies from a non-immune human Ab-phage library   using a novel panning strategy.

Application Notes

This antibody blocks the binding of MERS-CoV   spike protein to DPP4 receptor by binding to the aa 349-590 in the S1 domain of the MERS-CoV. This is a neutralizing antibody.

Antibody First   Published

Tang et al. Identification of human neutralizing antibodies against MERS- CoV and their role in virus adaptive evolution PNAS (2014) ; Issue: 19; Volume: 111; Pages: E2018–E2026. PMID:24778221

Note on publication

Describes the development and characterization of the antibody.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.