Key features and details | |
Cat. No. | MABL-475 |
Name | Anti-B7-H4 mAbs |
Clone No. | AFD- #36-1 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ELISA, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human B7-H4, which inhibits T cell proliferation and causes secretion of IL-2. It is overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). |
Alternative Name | B7H4; B7 homolog 4; B7h.5; O8E; Immune costimulatory protein B7-H4; B7S1; Protein B7S1; B7x; T-cell costimulatory molecule B7x; VTCN1 |
UniProt | Q7Z7D3 |
Immunogen | The original antibody was generated by immunizing BALB/c mice with recombinant human B7-H4 as immunogen. |
Application Notes | The binding specificity of this antibody towards B7-H4 was determined using ELISA. This antibody was used to screen B7-H4 positive human breast adenocarcinoma cell lines SKBR-3 using flow cytometry (US20180118831; Epstein Alan, 2013- B7-H4 as a Target for Breast Cancer Immunotherapy) |
Antibody First Published | Epstein et al. Car t-cells for the treatment of b7-h4 expressing solid tumors. US20180118831 |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
