Key features and details | |
Cat. No. | MABL-369 |
Name | Anti-Alpha Dystroglycan mAbs |
Clone No. | AFD- 1G12 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB, ELISA, FC, IF |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody specifically binds glycerol phosphate modifying group of human alpha dystroglycan. Alpha-dystroglycan (αDG) is an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. It is also a receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells and a receptor for laminin LAMA5. Defective glycosylation of alpha-dystroglycan is a biological marker for muscular dystrophydystroglycanopathy type A (MDDGA1), Walker-Warburg syndrome (WWS), muscle-eye-brain disease (MEB) and Fushan congenital muscle malnutrition (FCMD). |
Alternative Name | Dystroglycan 1; Dag1; αDG; Alpha-DG; α-DAG; ALPHA DAG; Dystroglycan; Dystrophin-associated glycoprotein 1; A-Dystroglycan; A Dystroglycan; Alpha-dystroglycan; α dystroglycan; α-dystroglycan; 2-1G12-1-26 |
UniProt | Q62165 |
Immunogen | The original antibody was generated by immunizing BALB/c micewith recombinant human αdistroglycan. |
Application Notes | The binding characterization of this antibody towards glycerol phosphate modifying group of alpha dystroglycan was done using ELISA. This antibody can recognize glycerol phosphate modifying group of alpha dystroglycan in an western blot and flow cytometric assay. This antibody can also be used for the immunofluorescence staining of colon cancer tissue (JP2022060048). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
