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Anti-SIRP alpha mAbs

简要描述:

This antibody recognises an epitope in the membrane most distal domain (D1) of SIRP alpha. It crossreacts with other SIRPs.

产品参数:

Cat. No.:MABL-2914

Species:Engineer

Species Reactivity:Human

Type:Recombinate

Application:binding assay, IP, WB, FC, IF

详细介绍

Key features and   details


Cat. No.

MABL-2914

Name

Anti-SIRP alpha mAbs

Clone No.

AFD- SAF10.1

From

Recombinant Antibody

Isotype

Engineer antibody

Application

binding assay, IP, WB, FC, IF

Species Reactivity

Human

Basic Information


Specificity

This antibody recognises an epitope in the   membrane most distal domain (D1) of SIRP alpha. It crossreacts with other   SIRPs.

Alternative Name

Tyrosine-protein phosphatase non-receptor   type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with   tyrosine-based activation motifs; Bit; CD172 antigen-like family member A;   Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen;   Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein   alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84;   CD172a

UniProt

P78324

Immunogen

This antibody was raised by immunisisng BALB/c   mice with an eukaryotically expressed SIRPα-Fc fusion protein consisting of   the extracellular domain and emulsified with complete Freund’s adjuvant and   followed by two subsequent boosts of SIRPα-Fc fusion protein emulsified with   IFA (Lee et al., 2007).

Application Notes

SAF10.1, can be used to detect SIRPs in a   wide variety of tissues and cell types. For instance, this antibody was   successfully used to detect SIRPs from COS7.2 cell lysates via Western blot   (Lee et al., 2008).

Antibody First   Published

Lee et al. Novel structural determinants on   SIRP alpha that mediate binding to CD47. J Immunol. 2007 Dec   1;179(11):7741-50. PMID:18025220

Note on publication

This article describes the generation and   characterisation of the SAF10.1 antibody.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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