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Anti-SIRP alpha mAbs

简要描述:

This antibody binds human and cynomolgus monkey SIRP alpha, which is a regulatory membrane glycoprotein and an immunoglobulin-like cell surface receptor for CD47. This protein plays a key role in intracellular signaling during synaptogenesis and in synaptic function. Cancer cells highly express CD47 that activates SIRPα and inhibit macrophage-mediated destruction.

产品参数:

Cat. No.:MABL-2913

Species:Engineer

Species Reactivity:Human, Cynomolgus Monkey

Type:Recombinate

Application:​Block, ELISA, FC

详细介绍

Key features and   details


Cat. No.

MABL-2913

Name

Anti-SIRP alpha mAbs

Clone No.

AFD- 12G6

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Block, ELISA, FC

Species Reactivity

Human, Cynomolgus Monkey

Basic Information


Specificity

This antibody binds human and cynomolgus   monkey SIRP alpha, which is a regulatory membrane glycoprotein and an   immunoglobulin-like cell surface receptor for CD47. This protein plays a key   role in intracellular signaling during synaptogenesis and in synaptic   function. Cancer cells highly express CD47 that activates SIRPα and inhibit   macrophage-mediated destruction.

Alternative Name

CD172a; SIRPα; SIRPA; Signal regulatory   protein α; Signal regulatory protein alpha; Tyrosine-protein phosphatase   non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like   molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like   family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor;   MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha- 1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84

UniProt

P78324

Immunogen

The original antibody was generated by immunizing   BALB/c mice with recombinant human SIRPα-hFc fusion protein.

Application Notes

The binding reactivity of this antibody   towards recombinant human SIRPα-his fusion protein was checked using ELISA.  Flow cytometry was used to detect the binding of the antibody to SIRPα on the   membrane of human and cynomolgus monkey SIRPα overexpressed cells. This   antibody binds cynomolgus monkey SIRPα with a weaker binding affinity than   human SIRPα. This antibody can effectively block the binding of CD47 protein   to cell surface SIRPα (CN110734897).

Antibody First   Published


Note on publication


COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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