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Anti-single-stranded poly(rI) RNA mAbs

简要描述:

Jel 103 is highly specific for single-stranded RNA and shows sequence specificity as it binds to poly(rI) but not to poly(dI), poly(rG) or to any other homopolymer - it does not bind randomly to calf thymus DNA. Jel 103 Fab is shown to form base stacking interactions with a Tyr residue and two salt-bridge interactions to the phosphate backbone with Lys and Arg residues.

产品参数:

Cat. No.:MABL-2912

Species:Engineer

Species Reactivity:Species independent

Type:Recombinate

Application:SPRIA, IF

详细介绍

Key features and   details


Cat. No.

MABL-2912

Name

Anti-single-stranded poly(rI) RNA mAbs

Clone No.

AFD- Jel 103

From

Recombinant Antibody

Isotype

Engineer antibody

Application

SPRIA, IF

Species Reactivity

Species independent

Basic Information


Specificity

Jel 103 is highly specific for   single-stranded RNA and shows sequence specificity as it binds to poly(rI)   but not to poly(dI), poly(rG) or to any other homopolymer - it does not bind   randomly to calf thymus DNA. Jel 103 Fab is shown to form base stacking   interactions with a Tyr residue and two salt-bridge interactions to the   phosphate backbone with Lys and Arg residues.

Alternative Name

polyriboinosinic acid; single stranded RNA;   single-stranded RNA; inosine

UniProt


Immunogen

Jel 103 was selected from a hybridoma cell   line generated by the fusion of the MOPC 315-43 myeloma cell line with mouse spleen cells derived from C57/B1 mice which had been immunized with   poly(rI)poly(dC) duplex complexed to methylated bovine serum albumin.

Application Notes

Jel 301 can be used for the detection of  single-stranded poly(rI) and for binding studies where the antibody has been   used previosly in solid-phase radioimmunoassays.

Antibody First   Published

Pokkuluri et al. Preparation,   characterization and crystallization of an antibody Fab fragment that   recognizes RNA. Crystal structures of native Fab and three Fab-mononucleotide   complexes. J Mol Biol. 1994 Oct 21;243(2):283-97. PMID:7523684

Note on publication

Describes the generation of jel 301 fab   fragment and the structures of the fab in complex with rIP, rGDP and dIMP are   reported.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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