Anti-RSPO2 mAbs

Cat. No.

MABL-2852

Name

Anti-RSPO2 mAbs

Clone No.

AFD- h130M23-H1L2

From

Recombinant Antibody

Isotype

Engineer antibody

Application

Blocking, in vitro, in vivo, SPR

Species Reactivity

Human, Mouse

Basic Information

Specificity

The antibody specifically reacts with human and mouse RSPO2.

Alternative Name

hRspo2; R-spondin-2; Roof plate-specific   spondin-2

UniProt

Q6UXX9

Immunogen

The antibody is the humanized version of the   murine 130M23.

Application Notes

The antibody was shown to completely block   β-catenin signaling, demonstrating it is a specific inhibitor of RSPO2. The   antibody blocked soluble RSPO2 binding to LGR5. The antibody had a binding affinity for human RSPO2 of 0.14 nM and mouse RSPO2 of 0.35 nM. The antibody   demonstrated strong anti-tumor growth activity in combination with   gemcitabine in a pancreatic xenograft model and inhibition of pancreatic   tumor growth in vivo as a single agent and in combination with additional   therapeutic agents. The humanized version of the antibody was produced. The   humanized version had a binding affinity for human RSPO2 of 0.13 nM   (US8802097B2).

Antibody First   Published

Note on publication

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.