Key features and details | |
Cat. No. | MABL-2778 |
Name | Anti-Pvs25 Surface Protein mAbs |
Clone No. | AFD- 2A8 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Blocking, ELISA |
Species Reactivity | Plasmodium vivax |
Basic Information | |
Specificity | The antibody binds to the 2B loop of Pvs25 with nanomolar affinity. |
Alternative Name | Ookinete Pvs25; Ookinete Surface Protein Pvs-25 |
UniProt | D9D8M0 |
Immunogen | Recombinant P.vivax Pvs25. |
Application Notes | This antibody binds to Pvs25, a Plasmodium surface protein constiting of a triangular arrangement of four epidermal growth-factor-like domainst tether on the cell by a glycosylphosphatidylinositol anchor. The antibody blocks the transmission of P. vivax to mosquitoes from the blood of a P. vivax-infected chimpanzee and from the blood of patients with vivax malaria. |
Antibody First Published | Saxena et al. Preparation, crystallization and preliminary X-ray analysis of a complex between the Plasmodium vivax sexual stage 25 kDa protein Pvs25 and a malaria transmission- blocking antibody Fab fragment Acta Crystallography Section D Biological Crystallography 2004; 60(Pt 11):2054-2057 PMID:15502325 |
Note on publication | Describes the generation of a murine monoclonal antibody against recombinant Pvs25 to prevent formaiton of P. vivax oocysts in mosquitoes. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
