欢迎来到西安迈博睿(Mabioway)生物科技有限公司 Call: 15339069646 | E-mail: info@mabioway.cn 在线留言 |

服务热线

15339069646
网站导航
当前位置: 首页 > 产品展示 > 抗体产品 > 一抗 > 其他抗体
其他抗体

Anti-Plakophilin 1 mAbs

简要描述:

This antibody recognizes Plakophilin-1. It binds the epitope within the first 27 amino acids from the N-terminal region and it does not cross react with Plakophilin 2 and Plakophilin 3. Plakophilins influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilin-1 is thought to play a role in junctional plaques and contribute to epidermal morphogenesis.

产品参数:

Cat. No.:MABL-2702

Species:Engineer

Species Reactivity:Human, Mouse

Type:Recombinate

Application:IP, WB, FC, IF, IHC

详细介绍

Key features and   details


Cat. No.

MABL-2702

Name

Anti-Plakophilin 1 mAbs

Clone No.

AFD- 10B2

From

Recombinant Antibody

Isotype

Engineer antibody

Application

IP, WB, FC, IF, IHC

Species Reactivity

Human, Mouse

Basic Information


Specificity

This antibody recognizes Plakophilin-1. It   binds the epitope within the first 27 amino acids from the N-terminal region   and it does not cross react with Plakophilin 2 and Plakophilin 3.   Plakophilins influence development and participate in linking cadherins to   cytoskeletal intermediate filaments. Plakophilin-1 is thought to play a role   in junctional plaques and contribute to epidermal morphogenesis.

Alternative Name

PKP1; PKP-1; Plakophilin-1; Band 6 protein;   B6P; PKP 1

UniProt

Q13835

Immunogen

This antibody was raised by immunizing mice   with the N-terminus of human Plakophilin-1 protein.

Application Notes

10B2 is recommedned for the detection and analysis of Plakophilin-1. In order to identify potential perturbations in   cell adherence, this antibody was used to detect plakophilin-1 in the skin   tissue of patients with epidermolysis bullosa via immunofluorescence (Pigors et al., 2011; pmid: 21320868). Further, this antibody was demonstrated to   have a potential diagnostic role in certain diseases, such as Ectodermal Dysplasia/Skin Fragility Syndrome where it was used to differentiate between a diseased and healthy skin samples (Sprecher et al., 2004; pmid: 15086548). It was also shown that 10B2 antibody can detect plakophilin-1 (PKP1) via Western blot (here: in HaCaT protein lysates) (Bonne et al., 2003; pmid: 12707304).

Antibody First   Published

Bonne et al. Defining desmosomal   plakophilin-3 interactions J Cell Biol. 2003 Apr 28;161(2):403-16.   doi:10.1083/jcb.200303036. Epub 2003 Apr 21. PMID:12707304

Note on publication

This article describes the earliest   characterization and usage of this anti-plakophilin 1 antibody.

COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


服务咨询

留言框

  • 标题:

  • 留言内容:

  • 您的单位:

  • 您的姓名:

  • 联系电话:

  • 常用邮箱:

  • 详细地址:

上一篇: Anti-PLAGL1 mAbs

下一篇: Anti-PLAP mAbs

推荐产品

联系我们

Copyright © 2012-2029 西安迈博睿(Mabioway)生物科技有限公司 版权所有

地址:陕西省西安市浐灞生态区广运潭大道南段4555号长安大学科技园4号楼A单元2层

电话:15339069646 邮箱:info@mabioway.cn

陕ICP备2021006339号