Key features and details | |
Cat. No. | MABL-2081 |
Name | Anti-IL-4 mAbs |
Clone No. | AFD- OX-81 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | Block, FC |
Species Reactivity | Rat |
Basic Information | |
Specificity | OX-81 binds specifically to IL-4. IL-4 is a globular signalling protein which is involved in the stimilation of activated B and T cell proliferation and the differentiation of B cells into plasma cells. IL-4 also regulates B cell class switching to IgE, upregulates MHC class II expression and plays a role in the inflammation response and wound repair. |
Alternative Name | BSF-1; OX81; MRC OX-81; MRC OX81; interleukin 4; interleukin-4; IL4; B- cell IGG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF1; Lymphocyte stimulatory factor 1 |
UniProt | P20096 |
Immunogen | OX-81 was prepared by immunizing BALB/c mice with full-length IL-4. |
Application Notes | OX-81 can be used to neutralise the effects produced by IL-4 and for FC studies. |
Antibody First Published | Mason et al.Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: evidencethat the protective mechanism depends on changes in the cytokine response and migratory properties of theautoantigen-specific T cells. J Exp Med. 1995 Aug 1;182(2):335-44. PMID:7543135 |
Note on publication | Describes the use of OX-81 in identifying the role of IL-4 in preventing EAE (experimental allergic encephalomyelitis) induction by anti-IgD-peptide pretreatment. Pretreatment with OX60-pep prevented the development of EAE it was observed that injection |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
