Key features and details | |
Cat. No. | MABL-2071 |
Name | Anti-IL-34 mAbs |
Clone No. | AFD- Ab2 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | crystallisation |
Species Reactivity | Human, Mouse |
Basic Information | |
Specificity | This antibody binds both human and murine IL-34. |
Alternative Name | Interleukin-34 |
UniProt | Q6ZMJ4 |
Immunogen | This antibody was generated by phage display, in which murine IL-34 was coated onto immunoplates and used as the antigen for antibody phage library sorting. |
Application Notes | This non-neutralising antibody binds to IL-34. A Fab fragment derived from this antibody has been used in crystallisation analysis of the structure of the active core of IL-34 (Ma et al, 2012). |
Antibody First Published | Ma et al. Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R. Structure. 2012 Apr 4;20(4):676-87 PMID:22483114 |
Note on publication | Describes the original generation of this antibody, and the use of FAb derived from this antibody to analyse the crystal structure of IL-34 |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
