Key features and details | |
Cat. No. | MABL-2023 |
Name | Anti-IL-12/IL-23p40 mAbs |
Clone No. | AFD- CNTO 1275 (Ustekinumab) |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | in vivo, therapeutic, Block |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody is specific for the p40 subunit of human IL-12/23. |
Alternative Name | p40; IL-12; IL-12p40; IL-12B; IL-23; IL-23p40 |
UniProt | |
Immunogen | The original antibody was produced by immunizing human immunoglobulin transgenic mice ((CBA/J×C57/BL6/J) F2 hybrid) with human recombinant IL-12. |
Application Notes | This antibody inhibits the interactions of IL-12 and IL-23 with the cell surface IL-12Rβ1 receptor and has been evaluated in phase I, II, and III trials as a treatment for immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn’s disease, multiple sclerosis, and ulcerative colitis (Elliott et al., 2009; PMID: 20074279) (Sands et al., 2019; PMID: 31553833). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
