Anti-FGFRIp mAbs

Cat. No.

MABL-1582

Name

Anti-FGFRIp mAbs

Clone No.

AFD- MI 7 A3

From

Recombinant Antibody

Isotype

Engineer antibody

Application

IP, RIA, WB

Species Reactivity

Rat, Human

Basic Information

Specificity

This antibody is specific for the common   FGFRl N-terminus and N-terminus of lg Loop II. FGFR is a tyrosine-protein   kinase that acts as cell-surface receptor for fibroblast growth factors and   plays an essential role in the regulation of embryonic development, cell   proliferation, differentiation and migration. Required for normal mesoderm   patterning and correct axial organization during embryonic development,   normal skeletogenesis and normal development of the gonadotropin-releasing   hormone (GnRH) neuronal system.

Alternative Name

Fibroblast growth factor receptor 1; FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD331

UniProt

P11362

Immunogen

Balb/c mice were immunized with recombinant human   FGF-R1a or with both recombinant human FGF-R1b and recombinant human FGF-R1a   .

Application Notes

To characterize this antibody a western blot   was preformed on sf9 cells transfected with baculovirus recombinantly   expressing the full length FGF-R1 protein. Furthermore immunoprecipitation   was preformed on the lysed sf9 cells transfected with baculovirus   recombinantly expressing the full length FGF-R1 protein. And finally a   radioimmunityassay was preformed with the mouse version of this antibody on   I125-labeled complexes (Xu et al, 1992; pmid:1325449).

Antibody First   Published

Xu et al. Expression and immunochemical   analysis of rat and human fibroblast growth factor receptor (flg) isoforms J   Biol Chem. 1992 Sep 5;267(25):17792-803. PMID:1325449

Note on publication

A panel of 16 isoform and domain-specific   polyclonal and monoclonal antibodies was developed and characterized.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.