Cat. No.
MABL-1071
Application
ICC, IP, WB
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
Y-2/131/47
From
Recombinant Antibody
Specificity
This antibody recognises human CD68 antigen. CD68 is a membrane glycoprotein highly expressed in monocytes and macrophages. It is involved in phagocytosis, lysosomal metabolism and interactions with pathogens and other cells.
Alternative Names
Macrosialin; Gp110; DKFZp686M18236; SCARD1; scavenger receptor class D, member 1; SRD1; SR-D1; CD68 molecule; CD68 antigen; Macrophage Antigen CD68; Y-2/131
UniProt
P34810
Immunogen
This antbody was raised by immunising mice with phytohaemagglutinin-activated peripheral blood mononuclear cells.
Application Notes
IP: Y-2/131/47 antibody was used for immunoprecipitation from the material from spleen membranes (Micklem et al., 1989). ICC: This antibody was also used in immunocytochemical staining of acute promyelocytic leukaemia cells in order to establish a characteristic phenotype of the diseased cells and develop a potential diagnostic tool of this disorder (Erber et al., 1994).
Antibody First Published
Micklem et al. A human macrophage-associated antigen (CD68) detected by six different monoclonal antibodies. Br J Haematol. 1989 Sep;73(1):6-11. PMID:2803980
Note on publication
This article characterises specificity of the Y-2/131/47 antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
