Cat. No.
MABL-908
Application
IP, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
HB7
From
Recombinant Antibody
Specificity
This antibody binds to an epitope between amino acids 273-285 of human CD38, an approximately 45 kDa type II transmembrane protein, expressed on essentially all pre-B lymphocytes, plasma cells, and thymocytes. Also present on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. Bimodally expressed during B cell development, modulating from high in immature cells to low in intermediate ones and back to high on mature B cells. This antibody competes with clone AT13/5 (Ab00289) (Ellis 1995).
Alternative Names
ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase; EC 3.2.2.5; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38; p45; NAD(+) nucleosidase
UniProt
P28907
Immunogen
Viable cells (1 x 10E7) of the human cell line, BJAB (Human Burkitt lymphoma B cell line), which was were injected intraperitoneally into 8-week-old BALB/c mice.
Application Notes
A customer reports successfully using this antibody (coupled to magnetic beads) for isolation of plasma cells from the intestinal lamina propria.
Antibody First Published
Tedder TF, Clement LT, Cooper MD. Discontinuous expression of a membrane antigen (HB-7) during B lymphocyte differentiation. Tissue Antigens. 1984 Sep;24(3):140-9. PMID:6440308
Note on publication
Describes the making of the antibody, shows it recognised HB-7 antigen protein using flow cytometry and immunoblotting.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
