Cat. No.
MABL-735
Application
IP, FC, IF
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
B88-9
From
Recombinant Antibody
Specificity
B88-9 binds to human CD16 at an epitope comprised of LEKDSVTK (aa 21-27), (SWKNTALH (aa 113-120), FHHNS (aa 134-138) and VGSKN (aa 158-162) (Feng et al, 2004). hCD16 is recognized by B88-9 when both bound and unbound to hIgG1 – B88-9-bound CD16 cannot be bound by hIgG1.
Alternative Names
Low Affinity IgR; Low affinity immunoglobulin gamma Fc region receptor III-A; CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc receptor III-2; FCGR3A; CD16A; FCG3; FCGR3; IGFR3; Fc-gamma receptor IIIb
UniProt
Q9ULV2
Immunogen
This antibody was raised against FCgRIII expressing cells.
Application Notes
This antibody binds to CD16, a low affinity Fc receptor on the surface of natural killer cells, neutrophils, monocytes and macrophages.
Antibody First Published
Tamm A, Schmidt RE. The binding epitopes of human CD16 (Fc gamma RIII) monoclonal antibodies. Implications for ligand binding. J Immunol. 1996 Aug 15;157(4):1576-81 PMID:8759741
Note on publication
Describes the characterization of this antibody.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
