Cat. No.
MABL-720
Application
ADCC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
059-053
From
Recombinant Antibody
Specificity
The antibody is specific for CD147. CD147 acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. Further, in association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors.
Alternative Names
5F7; TCSF; Basigin; Collagenase stimulatory factor; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; EMMPRIN; Hepatoma-associated antigen; HAb18G; Leukocyte activation antigen M6; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor
UniProt
P35613
Immunogen
The original antibody was isolated by panning a phage display library against CD147.
Application Notes
The IgG1 format of the antibody specifically bound to the cancer cells expressing CD147 (CCF-RC1, ACHN) and expresses the ADCC activity (US9388249B2).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
