Cat. No.
MABL-646
Application
Block, ELISA
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
11k2
From
Recombinant Antibody
Specificity
Binds to human CCL2.
Alternative Names
cytokine A2, MCP-1, Monocyte chemotactic factor 1, MCP-5, CCL12
UniProt
Immunogen
Human MCP-1.
Application Notes
This antibody binds to human CCL2, a small cytokine that recruits monocytes, memory T cells and dendritic cells to the sites of inflammation. Can block monocyte chemotaxis in cell migration assays (PMID
Antibody First Published
Lutgens E, Faber B, Schapira K, Evelo CT, van Haaften R, Heeneman S, Cleutjens KB, Bijnens AP, Beckers L, Porter JG, Mackay CR, Rennert P, Bailly V, Jarpe M, Dolinski B, Koteliansky V, de Fougerolles T, Daemen MJ. Gene Profiling in Atherosclerosis Reveals a Key Role for Small Inducible Cytokines Circulation. 2005 Jun 28;111(25):3443-52. Epub 2005 Jun 20. PMID:15967845
Note on publication
Describes time-related expression patterns in atherosclerosis and validation of the role of Mcps by generating and using the antibody 11k2.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
