Cat. No.
MABL-623
Application
SPR, WB
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
scFv 180
From
Recombinant Antibody
Specificity
This antibody binds specificially to the cardiac Troponin I Peptide KISASRKLQLKT. This epitope is 100% conserved among a great variety of mammalian species, including most monkeys, Squirrel, Hamster, Mouse, Rat, Rabbit, Whales, Mole-Rat, Antelope and several other mammals.
Alternative Names
TNNI3; cTnI; cTn-I
UniProt
P19429
Immunogen
Cardiac Troponin I peptide (KISASRKLQLKT).
Application Notes
Troponin I is the inhibitory subunit of troponin, the thin filament complex that confers calcium-sensitivity to muscle-actomyoisin ATPase activity. Cardiac Troponin I in the blood is also a marker for several heart muscle damages including myocardial infarction.
Antibody First Published
Conroy et al. Reconciling the structural attributes of avian antibodies. Journal of Biological Chemsitry 2014; 289(22)：15384-15392 PMID:24737329
Note on publication
Describes the use of phage display libraries to generate chicken antibodies against human cardiac troponin and PSA with subsequent crystallisation.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
