Cat. No.
MABL-512
Application
ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human, Mouse
Clone No.
P38G1
From
Recombinant Antibody
Specificity
This antibody recognizes human and mouse beta dystroglycan (β-DAG). Beta-dystroglycan is a transmembrane protein that plays an important role in connecting the extracellular matrix to the cytoskeleton. It plays an important role in linking dystrophin to the laminin-binding alpha-dystroglycan. It acts as a cell adhesion receptor in both muscle and non-muscle tissues. It also functions in cell adhesion- mediated signaling and implicated in cell polarity.
Alternative Names
Dystroglycan 1; Dag1; Beta-DG; β-DAG; BETA DAG; Dystroglycan; Dystrophin-associated glycoprotein 1; B-Dystroglycan; B Dystroglycan; Beta-dystroglycan; β dystroglycan; β-dystroglycan
UniProt
Q14118; Q62165
Immunogen
The original antibody was generated by immunizing BALB/c mice with a mixture of transfected HEK 293 cells expressing human and mouse β-DAG.
Application Notes
The binding specificity of this antibody to human and mouse beta dystroglycan expressed on the surface of CHO cells was confirmed using ELISA and flow cytometry. The binding affinity of the original IgG antibody to human beta dystroglycan was determined to be 941 pM. This antibody was used in combination with anti-Laminin antibody PL60B3 for the generation of a bispecific antibody (CN113651891).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
