Cat. No.
MABL-486
Application
Block, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
Ab-1
From
Recombinant Antibody
Specificity
The antibody binds to basigin with an affinity (Kd) of 4 nM reported for the original antibody.
Alternative Names
CD147; BSG; Cluster of differentiation 147; Extracellular matrix metalloproteinase inducer; EMMPRIN; 5F7; Collagenase stimulatory factor; Leukocyte activation antigen M6; Tumor cell-derived collagenase stimulatory factor; TCSF
UniProt
P35613
Immunogen
Recombinant ectodomains of human basigin.
Application Notes
The antibody binds specifically to basigin, a protein of the immunoglobulin superfamily which is expressed on the surface of erythrocyte and acts as a receptor for the human malaria parasite P. falciparum. The recombinant chimeric monoclonal antibody Ab-1 acts by blocking the interaction between basigin and PfRH5, a ligand necessary for the P. falciparum erythrocyte invasion, thereby inhibiting the development of malaria.
Antibody First Published
Zenonos ZA, Dummler SK, Müller-Sienerth N, Chen J, Preiser PR, Rayner JC, Wright GJ. Basigin is a druggable target for host-oriented antimalarial interventions. J Exp Med. 2015 Jul 27;212(8)：1145-51. PMID：26195724
Note on publication
Describes the development of the recombinant chimeric antibody Ab-1 directed against basigin, an erythrocyte receptor involved in parasite invasion.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
