Cat. No.
MABL-478
Application
crystallisation, FC, IF
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
17B1.3
From
Recombinant Antibody
Specificity
mAb 17B1.3 specifically recognises B7-H6. 17B1.3 reacted with human tumour cell lines constitutively expressing B7-H6 such as HeLa cells. Fab 17B1.3 does not interfere with the binding of B7-H6 to NKp30, but nevertheless blocks NK cell activation.
Alternative Names
B7H6; B7 homolog 6; Natural cytotoxicity triggering receptor 3 ligand 1; NCR3LG1; DKFZp686O2416
UniProt
Q68D85
Immunogen
Immunised mice with extracellular domain of human B7-H6 and selected on the basis of specific reactivity by P815.B7-H6, but not with P815.B7-H1.
Application Notes
B7-H6 is not detected in normal human tissues at steady state but is expressed on tumour cells, so tumour cells can be detected by NK cells. This article describes the study of the mechanisms that govern the induction of B7-H6 on primary cells as well as its consequences in vitro and in vivo.
Antibody First Published
Matta et al. Induction of B7-H6, a ligand for the natural killer cell–activating receptor NKp30, in inflammatory conditions Blood. 2013;122(3)：394-404 PMID：23687088
Note on publication
Matta et al.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
