Cat. No.
MABL-303
Application
FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
Ha5-1(5)2.1
From
Recombinant Antibody
Specificity
This antibody specifically binds to recombinant 24P4C12 expressing cells (PC3-24P4C12) and multiple cancer cell lines expressing 24P4C12.
Alternative Names
UniProt
Immunogen
The original antibody was generated by immunizing of human γ2 producing XenoMice with RAT(E)-24P4C12 cells.
Application Notes
This antibody was capable of binding cells expressing 24P4C12 proteins on their surface in a flow cytometric assay. This antibody can be used in the development of an antibody-drug conjugate for targeted delivery of toxins to cancerous cells. The cytotoxicity of Ha5-1(5)2.1-vcMMAE antibody-drug conjugates was evaluated in PC3 cells engineered to express 24P4C12 and it was reported that it can selectively deliver a cytotoxic drug to 24P4C12 expressing cells leading to their killing. Ha5- 1(5)2.1vcMMAE also inhibited the growth of subcutaneous and orthotopically established human androgen_x0002_independent prostate cancer xenograft in SCID mice (US8309093).
Antibody First Published
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
