Key features and details | |
Cat. No. | MABL-252 |
Name | Anti-TNFR2 mAbs |
Clone No. | AFD-5000000 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | therapeutic, Block, ELISA |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds human TNFR2 (TNFRSF1B). TNFR2 is a receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. |
Alternative Name | CD120b; TNFRSF1B; TNFBR; p75; TNF-R2; TNF-RII; TNFR-II; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor type II; p80 TNF-alpha receptor; Etanercept; 10-5E6; 5E6-mHvKv |
UniProt | P20333 |
Immunogen | The original antibody was generated by immunizing 6-8 weeks old female BALB/c mice with recombinant human TNFR2 protein. |
Application Notes | The binding characterization to human TNFR2 was done using ELISA. This antibody can effectively block the binding of TNFR2 with TNF alpha. The binding affinity of the original IgG antibody for human TNFR2 was determined using surface plasmon resonance and found to be Kd= 9.53 X 10^(-10) M. This antibody was also reported to show tumor inhibitory activity in b-HTNFR2 mice (colon cancer cells) (CN112480259). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
