Key features and details | |
Cat. No. | MABL-145 |
Name | Anti-Pan-Nav1 Na+ channel mAbs |
Clone No. | AFD-N419/40 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | ICC, WB |
Species Reactivity | Rat, Human, Mouse |
Basic Information | |
Specificity | This antibody binds to most Nav1 channels. Nav1 channels mediate the voltage-dependent sodium ion permeability of excitable membranes. |
Alternative Name | N419/40R; Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1; SCN1A |
UniProt | P35498 |
Immunogen | This antibody was raised by immunising BALB/c mice with a synthetic peptide amino acids 1501-1518 (TEEQKKYYNAMKKLGSKK, cytoplasmic loop between repeat III and IV) of human Nav1.1. |
Application Notes | This antibody was used for western blotting on adult rat brains (Gong et al, 2016; PMID:26644354). Immunocytochemistry on rat neurons was preformed with this antibody (Hefting et al, 2020; PMID:32116557) (Solé et al, 2019; PMID:30914445). |
Antibody First Published | Gong et al Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities N Biotechnol. 2016 Sep 25;33(5 Pt A):551-64. PMID:26644354 |
Note on publication | Describes the need for good antibodies usable is neurological research and the creation of these antibodies |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
