Key features and details | |
Cat. No. | MABL-118 |
Name | Anti-MMACHC mAbs |
Clone No. | AFD-N230/21 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | WB |
Species Reactivity | Human, Mouse |
Basic Information | |
Specificity | This antibody is specific for the MMACHC protein. MMACHC is a cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. |
Alternative Name | N230/21R; Cyanocobalamin reductase / alkylcobalamin dealkylase; Alkylcobalamin:glutathione S-alkyltransferase; CblC; Cyanocobalamin reductase (cyanide-eliminating); Methylmalonic aciduria and homocystinuria type C protein |
UniProt | Q9Y4U1 |
Immunogen | This antibody was raised by immunising BALB/c mice with a fusion protein amino acids 1-282 (full-length) of human MMACHC. |
Application Notes | This antibody was used to preform a western blot on lysated mouse embryos (Moreno- Garcia et al, 2014; PMID:24889031). |
Antibody First Published | Moreno-Garcia et al The Mmachc gene is required for pre-implantation embryogenesis in the mouse Mol Genet Metab. 2014 Jul;112(3):198-204. PMID:24889031 |
Note on publication | This article describes the research on the inheritance of the MMACHC gene in mice |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
