Key features and details | |
Cat. No. | MABL-080 |
Name | Anti-Kv4.3 K+ Channel mAbs |
Clone No. | AFD-K75/41 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IB, IHC |
Species Reactivity | Rat, Xenopus, Human, Mouse |
Basic Information | |
Specificity | This antibody is specific for Kv4.3. It does not cross-react with Kv4.2. |
Alternative Name | K75/41R; Potassium voltage-gated channel subfamily D member 3; Kcnd3 |
UniProt | Q62897 |
Immunogen | This antibody was raised by immunising BALB/c mice with a fusion protein consisting of the cytoplasmic C-terminus (amino acids 415-636) of rat Kv4.3. |
Application Notes | The specificity of this antibody has been confirmed in immunohistochemical analysis; while this antibody stains adult rat hippocampus sections (Andrews et al, 2019; PMID:30667360), brain sections from Kv4.3−/− mice remain blank (Burkhalter et al, 2006). This antibody has been used in immunoblot analysis of rat, mouse and frog brain membranes (Andrews et al, 2019; PMID:30667360).Additionally, this antibody has been used to assess Kv4.3 expression in mouse primary visual and primary somatosensory cortex through immunofluorescence imaging (Burkhalter et al, 2006). |
Antibody First Published | Burkhalter et al. Differential Expression of IA Channel Subunits Kv4.2 and Kv4.3 in Mouse Visual Cortical Neurons and Synapses Journal of Neuroscience 22 November 2006, 26 (47) 12274-12282 PMID:17122053 |
Note on publication | Describes the original use of this antibody. |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
