Cat. No.
MABL-3733
Application
immunosuppression, SPR, Block, FC, IHC
Isotype
Engineer antibody
Species Reactivity
Mouse
Clone No.
E18
From
Recombinant Antibody
Specificity
Recognises mouse CD28 at the interaction site with B7 and blocks binding to B7. Intact antibody (but not Fab fragments) trigger Treg proliferation in pro-inflammatory settings, and protect from graft-versus-host disease.
Alternative Names
TP44; T-cell-specific surface glycoprotein CD28; TP44
UniProt
P31041
Immunogen
Application Notes
Further functional characterisation of the antibody may be found here . This antibody does not comete with D665 (Ab00285).
Antibody First Published
Dennehy et al. Cutting Edge: Monovalency of CD28 Maintains the Antigen Dependence of T Cell Costimulatory Responses Journal of Immunology PMID:16670276
Note on publication
Cutting Edge: Monovalency of CD28 Maintains the Antigen Dependence of T Cell Costimulatory Responses
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
