Cat. No.
MABL-3722
Application
NTRL, ELISA
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
CDP 571 (Humicade)
From
Recombinant Antibody
Specificity
The antibody binds to human TNF-alpha with a Kd of 0.087 nM.
Alternative Names
TNFA; Tumour necrosis factor superfamily member 2; TNFSF2
UniProt
P01375
Immunogen
Human TNF-alpha
Application Notes
The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB.
Antibody First Published
Stephens et al. Comprehensive pharmacokinetics of a humanized antibody and analysis of residual anti-idiotypic responses. Immunology. 1995 Aug;85(4):668-74. PMID:7558164
Note on publication
CDR regions from murine antibody CB0010 specific for TNFalpha were engineered onto human gamma4 and kappa light chains to produce CDP571.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
