Cat. No.
MABL-3721
Application
in vivo, ELISA, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
cA2 (Infliximab)
From
Recombinant Antibody
Specificity
Binds to soluble and transmembrane forms of TNF-alpha and neutralizes its biological activity. Does not bind to TNF-beta.
Alternative Names
TNF-α; TNFα; TNFSF; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; TNFa
UniProt
P01375
Immunogen
Purified recombinant human TNF (rTNF).
Application Notes
This antibody can be used to detect and neutralize human TNF alpha. Unlike Adalimumab (Ab00718), Infliximab does not bind to mouse TNF alpha (Arnoult 2017, PMID: 28584008).
Antibody First Published
Knight DM, Trinh H, Le J, Siegel S, Shealy D, McDonough M, Scallon B, Moore MA, Vilcek J, Daddona P, et al. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol. 1993 Nov;30(16):1443-53. PMID:8232330
Note on publication
Describes the generation of a murine monoclonal antibody (A2) and its transformation to a mouse-human chimeric antibody (Ca2).
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
