Cat. No.
MABL-3684
Application
functional
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
SGN-33 (Lintuzumab)
From
Recombinant Antibody
Specificity
This antibody is specific for human CD33, which is restricted to cells of the myelomonocytic lineage. CD33 but does not appear in abundance on normal cells, but is over-expressed in AML and other myeloproliferative diseases.
Alternative Names
Sialic acid-binding Ig-like lectin 3; gp67; HuM195
UniProt
P20138
Immunogen
This humanized antibody was prepared by combining the CDR regions of the murine anti- CD33 M195 with human framework and constant regions.
Application Notes
In vitro, this antibody is capable of mediating ADCC against AML cells (Caron, 1998). Though shown to be safe in phase III trials, the use of this antibody in combination with induction chemotherapy did not result in a statistically significant improvement in response rate or survival in patients with refractory/relapsed AML (Feldman, 2005).
Antibody First Published
Co et al. Chimeric and humanized antibodies with specificity for the CD33 antigen Journal of immunology, 15 February 1992, Vol.148(4), pp.1149-54 PMID:1737932
Note on publication
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
