Cat. No.
MABL-3944
Application
RIA, SPR, FC
Isotype
Engineer antibody
Species Reactivity
Human
Clone No.
ML3-9 (C6ML3-9)
From
Recombinant Antibody
Specificity
This antibody is specific for HER2.
Alternative Names
CD340; ERBB2; MLN 1; NEU; NGL; Receptor tyrosine-protein kinase erbB- 2; Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase- type cell surface receptor HER2; p185erbB2; p185HER2; ML3.9; C6ML3.9
UniProt
P04626
Immunogen
Recombinant HER2/neu.
Application Notes
The antibody binds to human ErbB-2, a receptor tyrosine kinase (RTK) controlling cell growth and microtubule stabilization. Full-length antibody or Fab fragments cross-linked by secondary antibody had a growth-inhibiting effect onf ErbB-2 positive MDA-MB-453 cells. This effect was not seen with Fab fragments alone.
Antibody First Published
Itoh et al. Molecular structural and functional characterization of tumor suppressive anti-erbB-2 monoclonal antibody by phage display system. Journal of Biochemistry 2003; 133(2):239-245 PMID:12761188
Note on publication
Describes the generation of the SER4-monoclonal antibody and how the antibody inhibits cell growth in vitro.
Size
100 μg Purified antibody.
Concentration
1 mg/ml.
Purification
Protein A affinity purified
Buffer
PBS with 0.02% Proclin 300.
Storage Recommendation
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C.
