Anti-SARS-CoV S glycoprotein mabs [F26G10](MABL-3583)

Cat. No.

MABL-3583

Name

Anti-SARS-CoV S glycoprotein mabs 

Clone No.

F26G10

From

Recombinant Antibody

Isotype

Engineer antibody

Application

NTRL, ELISA, IF

Species Reactivity

SARSCoronavirus

Basic Information

Specificity

This antibody specifically binds the amino acids 318-510 in the S1 domain of the SARS-CoV Spike protein with a binding affinity of KD=7.5 (±2.7) nM.

Alternative Name

Spike protein; S protein; SARS-CoV S protein; S glycoprotein; E2; Peplomer protein; Spike protein S1

UniProt

P59594

Immunogen

The original antibody was generated by immunizing the BALB/C mice with the Tor-3 strain of the SARS-CoV.

Application Notes

This antibody is a SARS-CoV neutralizing antibody. F26G9 was capable of recognising both the S protein and the RBD in an ELISA. The neutralizing mAb, F26G10 specifically recognize SARS- HCoV   infected but not uninfected Vero cells in immunofluorescence Immunofluorescence (Berry et al, 2004).

Antibody First   Published

Berry et al. Development and characterisation of neutralising monoclonal antibody to the SARS-coronavirus   Journal of Virological Methods (2004); Issue: 1; Volume: 120; Pages: 87-96. PMID:15234813

Note on publication

Describes the development and characterization of the antibody.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.