Anti-Cardiac Troponin I mAbs

Cat. No.

MABL-623

Name

Anti-Cardiac Troponin I mAbs

Clone No.

AFD- scFv 180

From

Recombinant Antibody

Isotype

Engineer antibody

Application

SPR, WB

Species Reactivity

Human

Basic Information

Specificity

This antibody binds specificially to the   cardiac Troponin I Peptide KISASRKLQLKT. This epitope is 100% conserved among   a great variety of mammalian species, including most monkeys, Squirrel,   Hamster, Mouse, Rat, Rabbit, Whales, Mole-Rat, Antelope and several other   mammals.

Alternative Name

TNNI3; cTnI; cTn-I

UniProt

P19429

Immunogen

Cardiac Troponin I peptide (KISASRKLQLKT).

Application Notes

Troponin I is the inhibitory subunit of   troponin, the thin filament complex that confers calcium-sensitivity to   muscle-actomyoisin ATPase activity. Cardiac Troponin I in the blood is also a   marker for several heart muscle damages including myocardial infarction.

Antibody First Published

Conroy et al. Reconciling the structural   attributes of avian antibodies. Journal of Biological Chemsitry 2014; 289(22)：15384-15392   PMID:24737329

Note on publication

Describes the use of phage display libraries   to generate chicken antibodies against human cardiac troponin and PSA with  subsequent crystallisation.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity purified

Buffer

PBS with 0.02% Proclin 300.

Concentration

1 mg/ml.

Storage Recommendation

Store at 4⁰C for up to 3 months. For   longer storage, aliquot and store at - 20⁰C.