Key features and details | |
Cat. No. | MABL-2916 |
Name | Anti-SIRP- beta & gamma mAbs |
Clone No. | AFD- OX117 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | IP, ELISA, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds to human SIRP-beta and gamma. |
Alternative Name | CD172b/g; Human Signal Regulatory Protein gamma; Human Signal Regulatory Protein beta |
UniProt | Q9P1W8 |
Immunogen | Recombinant human SIRPγ:CD4 fusion protein. |
Application Notes | This antibody binds to human Signal-regulatory protein gamma, an immunoglobulin- like cell surface receptor binding CD47. It mediates cell-cell adhesion and enhances T-cell activation. |
Antibody First Published | Brooke et al. Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. Journal of Immunology 2004; 173(4):2562-2570 PMID:15294972 |
Note on publication | Describes the identification of a new member of the SIRP-family and its interaction with CD47 as well as the generation of a monoclonal antibody against it. |
COA Information (For reference only, actual COA shall prevail) | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |