Anti-SIRP- beta & gamma mAbs

Cat. No.

MABL-2916

Name

Anti-SIRP- beta & gamma mAbs

Clone No.

AFD- OX117

From

Recombinant Antibody

Isotype

Engineer antibody

Application

IP, ELISA, FC

Species Reactivity

Human

Basic Information

Specificity

This antibody binds to human SIRP-beta and   gamma.

Alternative Name

CD172b/g; Human Signal Regulatory Protein   gamma; Human Signal Regulatory Protein beta

UniProt

Q9P1W8

Immunogen

Recombinant human SIRPγ:CD4 fusion protein.

Application Notes

This antibody binds to human Signal-regulatory   protein gamma, an immunoglobulin- like cell surface receptor binding CD47. It   mediates cell-cell adhesion and enhances T-cell activation.

Antibody First   Published

Brooke et al. Human lymphocytes interact   directly with CD47 through a novel member of the signal regulatory protein   (SIRP) family. Journal of Immunology 2004; 173(4):2562-2570 PMID:15294972

Note on publication

Describes the identification of a new member   of the SIRP-family and its interaction with CD47 as well as the generation of   a monoclonal antibody against it.

COA Information （For reference only, actual COA shall prevail）

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.