Key features and details | |
Cat. No. | MABL-2845 |
Name | Anti-ROR1 mAbs |
Clone No. | AFD- M508 |
From | Recombinant Antibody |
Isotype | Engineer antibody |
Application | functional assay, ELISA, FC |
Species Reactivity | Human |
Basic Information | |
Specificity | This antibody binds the human ROR1. ROR1 is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. It is a pseudo kinase that lacks catalytic activity. Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes. |
Alternative Name | NTRKR1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; R12 |
UniProt | Q01973 |
Immunogen | The original antibody was generated by immunizing wild-type mice with full-length extracellular portion of human ROR1 protein. |
Application Notes | The binding reactivity of this antibody to full-length extracellular portion of human ROR1 protein and its truncated forms was done using ELISA. The binding reactivity and specificity of this antibody was comparable with another anti-ROR1 antibody R12. The mouse-human chimeric IgG1 version of this antibody binds human ROR1 with a binding affinity of Kd= 1.4 nM. This antibody could bind human ROR1 expressed on the surface of breast cancer cell line MDA-MB-231 in a flow cytometric assay. This antibody is recommended for detection of human ROR1 expressing tumor cells (CN114539411). |
Antibody First Published | |
Note on publication | |
COA Information （For reference only, actual COA shall prevail） | |
Size | 100 μg Purified antibody. |
Concentration | 1 mg/ml. |
Purification | Protein A affinity purified |
Buffer | PBS with 0.02% Proclin 300. |
Concentration | 1 mg/ml. |
Storage Recommendation | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at - 20⁰C. |
