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Anti-ROR1 mAbs

简要描述:

This antibody binds the human ROR1. ROR1 is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. It is a pseudo kinase that lacks catalytic activity. Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Antibody-based immunotherapies targeting ROR1 have been developed and evaluated in preclinical and clinical studies with promising outcomes.

产品参数:

Cat. No.:MABL-2845

Species:Engineer

Species Reactivity:Human

Type:Recombinate

Application:functional assay, ELISA, FC

详细介绍

Key features and   details


Cat. No.

MABL-2845

Name

Anti-ROR1 mAbs

Clone No.

AFD- M508

From

Recombinant Antibody

Isotype

Engineer antibody

Application

functional assay, ELISA, FC

Species Reactivity

Human

Basic Information


Specificity

This antibody binds the human ROR1. ROR1 is a   type I membrane protein and belongs to the ROR subfamily of cell surface   receptors. It is a pseudo kinase that lacks catalytic activity. Receptor   tyrosine kinase ROR1 plays an essential role in embryogenesis and is   overexpressed in many types of malignant tumors. Antibody-based   immunotherapies targeting ROR1 have been developed and evaluated in   preclinical and clinical studies with promising outcomes.

Alternative Name

NTRKR1; Inactive tyrosine-protein kinase   transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; R12

UniProt

Q01973

Immunogen

The original antibody was generated by immunizing wild-type mice with full-length extracellular portion of human ROR1 protein.

Application Notes

The binding reactivity of this antibody to full-length extracellular portion of human ROR1 protein and its truncated   forms was done using ELISA. The binding reactivity and specificity of this   antibody was comparable with another anti-ROR1 antibody R12. The mouse-human   chimeric IgG1 version of this antibody binds human ROR1 with a binding   affinity of Kd= 1.4 nM. This antibody could bind human ROR1 expressed on the   surface of breast cancer cell line MDA-MB-231 in a flow cytometric assay.   This antibody is recommended for detection of human ROR1 expressing tumor   cells (CN114539411).

Antibody First   Published


Note on publication


COA Information For reference only, actual COA shall prevail

Size

100 μg Purified   antibody.

Concentration

1 mg/ml.

Purification

Protein A affinity   purified

Buffer

PBS with 0.02% Proclin   300.

Concentration

1 mg/ml.

Storage   Recommendation

Store at 4⁰C for up to 3   months. For longer storage, aliquot and store at - 20⁰C.


 


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